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Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci
Internal Dataset- Authors
- Maria Gutierrez-ArcelusYuriy BaglaenkoJatin AroraSusan Hannes14 more author(s)...
- Description
In this study we sought to analyze the effects of genetic variants on gene regulation in a cell-state dependent manner during CD4 memory T cell activation. To do this, we performed an RNA-seq time series experiment on CD4 memory T cells activated with anti-CD3/CD28 beads in individuals with no autoimmune disease. We measured gene expression levels, and allele-specific expression at heterozygous sites...
- Subject
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AutoimmunityGenetic VariationHLA AntigensHLA-DQ beta-ChainsLymphocyte ActivationPromoter Regions, GeneticRNA-Seq
- Access Rights
- Free to AllFree to all with registrationApplication Required
- Local Expert
- Peter Gregersen
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IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
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Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen
